Potential of natural antioxidant compound in Cymbopogon nardus as anti-cancer drug via HSP-70 inhibitor

Citronella grass (Cymbopogon nardus) is a plant containing many metabolite compounds which prevent and treat various diseases, one of cancer. Antioxidant found in citronella have been shown to improve the immune system by increasing cytokines. The activity changing homeostasis generates free radicals. Free radicals causing protein damage so that Heat Shock Protein-70 (HSP70) overexpressed. HSP70 has role as chaperon. Mutations anti-apoptotic are causes This current research aims determine potential present stem anti-cancer through inhibition HSP-70. method was bioinformatics approach, namely in-silico provided simulation binding ligands HSP-70 inhibitor mechanism. results this study indicated there for compounds, spathulenol Spathulenol interact with Hsp70 via positions Thr204, Gly12, Gly203, Thr14, Lys71, Asp10, Val369, Asp199, Val337, Gly338, Asp366, Gly339, Pro365, Glys201, & Glys202 Van der Waals bonds hydrogen on Thr13. In complex, unfavorable bond formed O atom query ligand. From above, it can be concluded compound predicted act an because inhibits site native ligand Hsp70. stability interaction produced allows response activity. By inhibiting inhibitors, possible inhibit formation proliferation cancer cells